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Edgar B. Smith, MD

Arch Dermatol. 1989;125(2):216-218.

Abstract
• Two clinical trials were performed to determine the relative efficacy of tioconazole, a new antifungal agent for treating patients with tinea pedis. One study compared the new agent with a placebo cream and the other with miconazole nitrate, an established effective antifungal agent. The investigators found a much higher "cure" rate for tioconazole when both treatment groups were known to receive active agents than the cure rate for tioconazole found in the placebo-controlled study. These results showed that the expectations of investigators can influence their clinical evaluations. Such bias could also influence the results of clinical trials.

(Arch Dermatol 1989;125:216-218)

Author Affiliations
From the Department of Dermatology, University of Texas Medical Branch, Galveston.

Footnotes
Accepted for publication Sept 6, 1988.

Reprint requests to Department of Dermatology, University of Texas Medical Branch, Galveston, TX 77550 (Dr Smith).

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