This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (29)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Neal S. Penneys, MD; Jai K. Nayar, PhD; Helene Bernstein; Judy W. Knight; Craig Leonardi, MD

Arch Dermatol. 1989;125(2):219-222.

Abstract
• Salivary glands were removed from female mosquitoes of laboratory-reared strains of species common to southern Florida. Protein antigens were isolated from homogenates of these glands by denaturing electrophoresis and transferred to nitrocellulose for immunoblotting with serum samples obtained from human volunteers. A spectrum of antigens with a wide range of molecular weights (14 to 126 kilodaltons) were identified by antibodies in human serum for each species. Both speciesunique and species-shared antigens were present. The results of these studies indicate that the humoral response to mosquito bite is complex, with a multitude of antigens provoking antibody responses. Since each individual has his or her own unique exposure history to mosquitoes, it seems unlikely that desensitization to a specific immunogen will confer protection in clinical situations in which multiple exposures to a variety of mosquito species occur.

(Arch Dermatol 1989;125:219-222)

Author Affiliations
From the Department of Dermatology, University of Miami School of Medicine (Drs Penneys and Leonardi and Ms Bernstein), and the Florida Medical Entomology Laboratory, Institute of Food and Agricultural Sciences, University of Florida, Vero Beach (Dr Nayar and Ms Knight).

Footnotes
Accepted for publication Sept 23, 1988.

Reprint requests to Department of Dermatology R-11, PO Box 016960, University of Miami School of Medicine, Miami, FL 33101 (Dr Penneys).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?