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Vincent A. Ziboh, PhD

Arch Dermatol. 1989;125(2):241-245.

Abstract
• A major proinflammatory metabolite of arachidonic acid, leukotriene B₄, is known to accumulate in the lesions of psoriasis. Most of this metabolite is biosynthesized by the polymorphonuclear cells that infiltrate into the psoriatic lesions. Epidermal 15-lipoxygenase, on the other hand, metabolizes arachidonic acid into 15-hydroxyeicosatetraenoic acid (15-20:4n-6), presumably serving as a negative feedback to inhibit the local generation of leukotriene B₄-Eicosapentaenoic acid, a major polyunsaturated fatty acid in fish oil, and -linolenic acid, a poly-unsaturated fatty acid in certain vegetable oils, are both metabolized by epidermal 15-lipoxygenase into 15-hydroxyeicosapentaenoic acid (15-OH-20:5n-3) and 15-hydroxyeicosatriaenoic acid (15-OH-20:3n-3), respectively. Both of these monohydroxy acids are potent in vitro inhibitors of leukotriene B⁴ generation. It seems reasonable, therefore, that adequate dietary supplementation with eicosapentaenoic acid or -linolenic acid may offer a novel and nontoxic approach to suppressing cutaneous inflammatory disorders.

(Arch Dermatol 1989;125:241-245)

Author Affiliations
From the Department of Dermatology, School of Medicine, University of California at Davis.

Footnotes
Accepted for publication July 29, 1988.

Read before the Festschrift and Celebration for Harvey Blank, MD, University of Miami, Feb 19-20, 1988.

Reprint requests to Department of Dermatology, TB 192, School of Medicine, University of California at Davis, Davis, CA 95616 (Dr Ziboh).

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