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The Immune Network

M. Joyce Rico, MD; Russell P. Hall III, MD

Arch Dermatol. 1989;125(2):271-275.

Abstract
• Antibodies specific for determinants within the variable region of an antibody molecule are known as anti-idiotypic antibodies. Anti-idiotypic antibodies specific for determinants within the antigen binding site of the antibody may mimic the original antigen and are said to bear an "internal image" of the antigen. These anti-idiotypic antibodies have been shown in animal studies to function as surrogate antigens in stimulating an immune response and may ultimately be useful therapeutically as vaccines to prevent infectious diseases, to enhance the immune response to neoplasms, and to modulate autoantibody production in autoimmune diseases.

(Arch Dermatol 1989;125:271-275)

Author Affiliations
From the Department of Medicine, Division of Dermatology, Duke University Medical Center, Durham, NC.

Footnotes
Accepted for publication Aug 16, 1988.

Read in part before the Festschrift honoring Harvey Blank, MD, Miami, Feb 20, 1988.

Reprint requests to Division of Dermatology, Box 3135, Duke University Medical Center, Durham, NC 27710 (Dr Rico).

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