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Jo-David Fine, MD; Tsunenobu Tamura, MD; Lorraine Johnson, RN, ScD

Arch Dermatol. 1989;125(3):374-379.

Abstract
• Plasma or erythrocyte levels of ten nutrients (vitamins A, C, B_1,2 and B₆; folate; thiamine; riboflavin; zinc; copper; iron) were assayed in 73 patients with various forms of inherited epidermolysis bullosa (EB). Whereas the mean level for each nutrient was within its normal range, deficient levels were noted in individual EB subsets for selected nutrients. Notable abnormalities included low levels of plasma iron and zinc (in junctional EB and recessive dystrophic EB), vitamin C (primarily in EB simplex), vitamin A (in junctional and recessive dystrophic EB), vitamin B₁₂ (primarily in EB simplex), and vitamin B₆ (especially in recessive dystrophic EB). With the exception of low plasma iron and zinc levels in junctional and recessive dystrophic EB, however, only a minority of patients in any of the EB subsets had low levels of most of the other nutrients, and an apparent correlation with malabsorption was possible with only selected nutrients.

(Arch Dermatol 1989;125:374-379)

Author Affiliations
From the Departments of Dermatology (Dr Fine and Ms Johnson) and Nutrition Sciences (Dr Tamura), University of Alabama at Birmingham School of Medicine; and the Dermatology Section, Medical Service (Dr Fine), Birmingham (Ala) Veterans Administration Medical Center.

Footnotes
Accepted for publication Nov 13, 1988.

Reprint requests to Department of Dermatology, University of Alabama at Birmingham, UAB Station, Box 76, Birmingham, AL 35294 (Dr Fine).

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