This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Richard L. Gallo, MD, PhD; Richard D. Granstein, MD

Arch Dermatol. 1989;125(4):502-506.

Abstract
• Amiloride is known to inhibit membrane sodium transport and has been shown in vitro to inhibit cell activation and proliferation in several model systems. These effects occur at relatively high local concentrations of amiloride. We studied the cutaneous response to the topical application of amiloride hydrochloride. Our observations demonstrated that topical application of amiloride was potent in its ability to inhibit murine tissue swelling and inflammation in response to contact sensitizing agents and ultraviolet radiation. These observations might suggest a role for amiloride or its analogues as topical anti-inflammatory or antiproliferative drugs.

(Arch Dermatol. 1989;125:502-506)

Author Affiliations
From the Wellman Laboratory, Department of Dermatology, Massachusetts General Hospital, Boston.

Footnotes
Accepted for publication December 13, 1988.

Reprint requests to Wellman Laboratory, Department of Dermatology, Massachusetts General Hospital, Boston, MA 02114 (Dr Gallo).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Amiloride Blockades Lipopolysaccharide-Induced Proinflammatory Cytokine Biosynthesis in an Ikappa B-alpha /NF-kappa B-Dependent Mechanism . Evidence for the Amplification of an Antiinflammatory Pathway in the Alveolar Epithelium
Haddad and Land
Am. J. Respir. Cell Mol. Bio. 2002;26:114-126.
ABSTRACT | FULL TEXT