This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (18)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Vincent C. Ho, MD, FRCPC; Aditya K. Gupta, MD; Charles N. Ellis, MD; Kevin D. Cooper, MD; Brian J. Nickoloff, MD, PhD; John J. Voorhees, MD

Arch Dermatol. 1989;125(4):511-514.

Abstract
• In an open trial, five patients with lamellar ichthyosis showed no response to four weeks of treatment with oral cyclosporine (cyclosporine A) (6 mg/kg/d). Histologic examination of lamellar ichthyosis revealed hyperkeratosis; psoriasiform acanthosis; dilated, tortuous capillaries; and a slight perivascular lymphocytic infiltrate. Immunofluorescence studies revealed, in the epidermis, normal numbers of T6+DR+ Langerhans' cells and an absence of T cells and intercellular adhesion molecule-1 expression. In the papillary dermis, there were prominent capillaries as detected by staining with anti-factor VIII-related antigen. The endothelial cells also expressed large amounts of HLA-DR and intercellular adhesion molecule-1, suggesting that they were activated. Only occasional Langerhans' cells were found in the dermis. Histologic and immunofluorescence findings were unchanged with cyclosporine therapy. The effects of cyclosporine on lamellar ichthyosis are contrasted with those reported for psoriasis. Since lamellar ichthyosis and psoriasis share similar features of epidermal hyperproliferation and the presence of activated, dilated, tortuous vessels, but differ in the lack of immunologic cellular activity, their contrasting response to cyclosporine suggests that the target of the action of cyclosporine is the immune system rather than the keratinocyte or the endothelium. However, other factors may have to be considered.

(Arch Dermatol 1989;125:511-514)

Author Affiliations
From the Departments of Dermatology (Drs Ho, Gupta, Ellis, Cooper, Nickoloff, and Voorhees) and Pathology (Dr Nickoloff), University of Michigan Medical Center, Ann Arbor, and the Dermatology Service, Ann Arbor Veterans Administration Hospital (Dr Cooper). Dr Ho is now a fellow with the Department of Dermatology, Harvard University School of Medicine, Boston.

Footnotes
Accepted for publication Aug 31, 1988.

Reprint requests to Department of Dermatology, University of Michigan Medical Center, Room 1910 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0314 (Dr Voorhees).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Oral Cyclosporine in the Treatment of Inflammatory and Noninflammatory Dermatoses: A Clinical and Immunopathologic Analysis
Gupta et al.
Arch Dermatol 1990;126:339-350.
ABSTRACT  

Cyclosporine: An Immunosuppressant Affecting Epithelial Cell Proliferation
Kanitakis and Thivolet
Arch Dermatol 1990;126:369-375.
ABSTRACT