 |
|
Long-term Follow-up of Skin Cancer in the PUVA-48 Cooperative Study
Amy B. Forman, MD;
Henry H. Roenigk, Jr, MD;
William A. Caro, MD;
Morgan L. Magid, MD
Arch Dermatol. 1989;125(4):515-519.
Abstract
| |
• Five-hundred fifty-one psoriasis patients receiving therapy with psoralen plus UVA light in seven medical centers for up to 10 years were evaluated for the development of skin cancer. Basal cell carcinoma developed in 13 patients (2.4%), and squamous cell carcinoma (SCC) developed in 9 (1.6%), an incidence that is significantly elevated over that in the general population. The increase in basal cell carcinoma was found only in patients with exposure to other carcinogenic agents, whereas the increase in SCC was also seen in patients without such exposures. Cumulative UVA dosage was not correlated with the development of basal cell carcinoma, but there was a trend of increasing numbers of SCCs in patients with higher dosages. Five of 9 patients had SCCs on sites that were not sun exposed. All patients with tumors had them treated surgically, and, to date, none have recurred. This study confirms a previous report of an increase in the incidence of SCC in psoriatic patients treated with PUVA.
(Arch Dermatol. 1989;125:515-519)
Author Affiliations
From the Department of Dermatology, Northwestern University Medical Center, Chicago, Ill.
Footnotes
Accepted for publication January 23, 1989.
Presented as a poster at the Society for Investigative Dermatology, Washington, DC, April 27-29, 1988. Presented, in part, at the American Academy of Dermatology annual meeting, Washington, DC, December 3-8, 1988.
Reprint requests to Northwestern University Department of Dermatology, 303 E Chicago Ave, Ward Building, Third Floor, Chicago, IL 60611 (Dr Forman).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Cutaneous Squamous-Cell Carcinoma
Alam and Ratner
NEJM 2001;344:975-983.
FULL TEXT
Secondary Malignant Neoplasms in 71 Patients With Sezary Syndrome
Scarisbrick et al.
Arch Dermatol 1999;135:1381-1385.
ABSTRACT
| FULL TEXT
Trimethylpsoralen Bath PUVA Is a Remittive Treatment for Psoriasis Vulgaris: Evidence That Epidermal Immunocytes Are Direct Therapeutic Targets
Coven et al.
Arch Dermatol 1998;134:1263-1268.
ABSTRACT
| FULL TEXT
Regulatory Perspective on in Vitro Assays as Predictors of Phototoxicity and Photo Co-Carcinogenicity
Ellis
International Journal of Toxicology 1998;17:571-575.
ABSTRACT
Consensus Workshop on the Toxic Effects of Long-term PUVA Therapy
Morison et al.
Arch Dermatol 1998;134:595-598.
ABSTRACT
| FULL TEXT
The Therapy of Oral Lichen Planus
Eisen
CROBM 1993;4:141-158.
ABSTRACT
| FULL TEXT
Comparison of the Carcinogenic Potential of Trioxsalen Bath PUVA and Oral Methoxsalen PUVA: A Preliminary Report
Lindelof et al.
Arch Dermatol 1992;128:1341-1344.
ABSTRACT
Risk Assessment of PUVA and Cyclosporine: Lessons From the Past; Challenges for the Future
Stern
Arch Dermatol 1989;125:545-547.
ABSTRACT
|
