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Ronald S. Ostrow, PhD; M. Kathy Shaver, MS; Sarah Turnquist; Ann Viksnins, MS; Mitchell Bender, MD; Corwin Vance, MD; Valda Kaye, MD; Anthony J. Faras, PhD

Arch Dermatol. 1989;125(5):666-669.

Abstract
• A middle-aged man with a 20-year history of a warty lesion on his finger was diagnosed histologically as having an invasive carcinoma at that location. Molecular analysis of the lesion showed that human papillomavirus (HPV) DNA was present in this tumor. Under stringent hybridization conditions, only HPV-16 DNA, which is commonly associated with genital neoplasia or cutaneous bowenoid lesions, was detected. Two-dimensional gel electrophoresis revealed that various sections of the tumor contained mostly episomal viral DNA; but in one case, low levels of integrated HPV-16 DNA were detected as well.

(Arch Dermatol 1989;125:666-669)

Author Affiliations
From the Departments of Microbiology (Drs Ostrow and Faras and Mss Shaver, Turnquist, and Viksnins), Dermatology (Drs Bender, Vance, and Kaye), and Laboratory Medicine and Pathology (Dr Kaye) and the Institute of Human Genetics (Drs Ostrow and Faras), School of Medicine, University of Minnesota, Minneapolis.

Footnotes
Accepted for publication Nov 15, 1988.

Reprint requests to Box 206 UMHC, Institute of Human Genetics, University of Minnesota, Harvard Street at East River Road, Minneapolis, MN 55455 (Dr Ostrow).

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