This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Genetic Markers and Clinical and Immunological Findings in Patients

Eija Johansson-Stephansson, MD; Saija Koskimies; Jukka Partanen, MD; Arja-Leena Kariniemi

Arch Dermatol. 1989;125(6):791-796.

Abstract
• The role of HLA and complement genes was studied in 13 patients with subacute cutaneous lupus erythematosus by combining the major histocompatibility complex class I (HLA-A, -B, and -C), class II (HLA-DR), and class III (properdin factor B [BF] and C4) phenotyping with DNA level analysis of the C4 region. Of our patients, 54% had DR2 antigens and 50% had DR3 antigens, when the frequencies in the controls were 25% and 33%, respectively. The DR3 antigen was associated with annular skin lesions that were associated with a younger age at onset, whereas the DR2 antigen was associated with papulosquamous skin lesions and an older age at onset. The frequency of C4 null alleles was 83% in the patients and 50% in the controls. The null alleles were found in both C4A and C4B loci and were not associated with any special major histocompatibility complex haplotype. The DNA studies showed that the null phenotype mostly resulted from a gene deletion. A highly increased frequency of complement C4 null alleles may be a predisposing factor for cutaneous lupus erythematosus and especially of the subacute cutaneous type.

(Arch Dermatol. 1989;125:791-796)

Author Affiliations
From the Department of Dermatology, Karolinska Hospital, Stockholm, Sweden (Dr Johansson-Stephansson), the Department of Dermatology, University Central Hospital (Ms Kariniemi), and the Finnish Red Cross Blood Transfusion Service, Tissue Typing Laboratory (Ms Koskimies and Dr Partanen), Helsinki, Finland.

Footnotes
Accepted for publication February 13, 1989.

Reprint requests to Department of Dermatology, Karolinska Hospital, 10401 Stockholm, Sweden (Dr Johansson-Stephansson).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cross-sectional Analysis of a Collaborative Web-Based Database for Lupus Erythematosus-Associated Skin Lesions: Prospective Enrollment of 114 Patients
Moghadam-Kia et al.
Arch Dermatol 2009;145:255-260.
ABSTRACT | FULL TEXT  

Antimalarials in cutaneous lupus erythematosus: mechanisms of therapeutic benefit
Wozniacka et al.
Lupus 2002;11:71-81.
ABSTRACT  

Epidemiology and socioeconomic impact of skin disease in lupus erythematosus
Tebbe and Orfanos
Lupus 1997;6:96-104.
ABSTRACT