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Mediators of Inflammation in Blister Fluids From Patients With Pemphigus Vulgaris and Bullous Pemphigoid
Sergei A. Grando, CandSci(Med);
Boris T. Glukhenky, DSci(Med);
George N. Drannik, DSci(Med);
Evsey V. Epshtein, DSci(Med);
Alexander P. Kostromin, DSci(Biol);
Taras A. Korostash
Arch Dermatol. 1989;125(7):925-930.
Abstract
• Blister fluids from 39 previously untreated patients with pemphigus vulgaris (PV) and 28 patients with bullous pemphigoid (BP) were tested for the presence of inflammatory mediators. Blister fluids from patients with PV and BP showed interleukin 1 (IL-1)- and interleukin 2 (IL-2)-like activity and contained prostaglandin (PG) E2, F1 , and F2, thromboxane B2 (TB2), leukotriene (LT) B4 and C4, serine esterases, and proteolysis inhibitors. Pemphigus blister fluid was distinguished by high IL-1-like activity, proteolytic activity, and high concentrations of TB2 and LTB4, while pemphigoid blister fluid was characterized by higher IL-2-like activity, antiprotease activity, and high PGE2 concentration. We also determined that the content of mediators of inflammation varied depending on the duration of blister development. In both PV and BP, the initially high IL-1-like activity, amount of serine proteases, and concentrations of PGF2, TB,2 LTB4, and LTC4 decreased by the fifth day of blister existence, whereas antiprotease activity as well as PGE2 and PGF1 concentrations gradually increased as blisters developed. These findings suggest certain differences in the character of the bullous inflammatory process in pemphigus and pemphigoid.
(Arch Dermatol 1989;125:925-930)
Author Affiliations
From the Unit of Immunodermatology (Dr Grando) and Chair of Dermato-Venereology (Drs Grando and Glukhenky and Mr Korostash), Kiev (USSR) State Advanced Training Institute for Doctors; Centre for Clinical and Experimental Immunology, UkrSSR Academy of Sciences and Ministry of Health, Kiev (Dr Drannik); Radioimmunology Laboratory, Kiev, Institute of Endocrinology (Dr Epshtein); and Laboratory of Immunobiology, Kiev State University (Dr Kostromin).
Footnotes
Accepted for publication Sept 15, 1988.
Reprint requests to Chair of Dermato-Venereology, KGIUV, GKVD-2, 72 Saksagansky St, Kiev-32, 252032 USSR (Dr Grando).
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