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Christine Jaworsky, MD; George F. Murphy, MD

Arch Dermatol. 1989;125(7):963-974.

Abstract
• Beyond routine hematoxylin-eosin histologic examinations, specialized diagnostic techniques allow examination of biopsy material for subtle morphological and functional alterations. Morphological analytic techniques (1-µm section analysis, transmission electron microscopy, x-ray probe microanalysis, and digital image analysis) and functional analytic techniques (immunofluorescence, immunohistochemistry, and molecular biologic techniques) are valuable diagnostic tools. These techniques have applications in evaluating cutaneous T-cell lymphoma and atypical lymphocytic infiltrates, vesiculobullous disorders, lupus erythematosus and collagen vascular diseases, vasculitis, poorly differentiated tumors, storage diseases, and infections.

(Arch Dermatol. 1989;125:963-974)

Author Affiliations
From the Division of Dermatopathology, Department of Dermatology, University of Pennsylvania, Philadelphia.

Footnotes
Accepted for publication February 23, 1989.

Reprint requests to Department of Dermatology, University of Pennsylvania, 329 Medical Education Bldg, 36th and Hamilton Walk, Philadelphia, PA 19104 (Dr Jaworsky).

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