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Merkel Cell CarcinomaA Successful Treatment With Tumor Necrosis Factor
Yoshiko Ito, MD;
Kuniko Kawamura, MD;
Takako Miura, MD;
Kowichi Ueda, MD;
Hideo Onodera, MD;
Hiroyuki Takahashi, MD;
Takashi Horikoshi, MD;
Sadao Sugiyama, MD;
Makoto Takahashi, MD
Arch Dermatol. 1989;125(8):1093-1095.
Abstract
• A Merkel cell carcinoma of the mandibular area in a 78-year-old woman was treated successfully by direct intratumoral administration of recombinant human tumor necrosis factor. The patient received 2.5 x 105 U/d of recombinant human tumor necrosis factor every other day. A total of six injections (total dose, 1.5 x 106 U, 0.52 mg of protein) were administered over a period of 12 days. Soon after the therapy ended, the lesion softened and decreased in size. After 1 month, only erythema was visible. The lesion had completely disappeared clinically and histologically 5 months after the local injection of recombinant human tumor necrosis factor. Neither recurrence nor metastasis has been observed for at least 12 months following the treatment. Recombinant human tumor necrosis factor is suggested to be effective for the treatment of Merkel cell carcinoma.
(Arch Dermatol. 1989;125:1093-1095)
Author Affiliations
From the Department of Dermatology, Sapporo (Japan) Medical College.
Footnotes
Accepted for publication January 10, 1989.
Presented as a poster at the 87th Annual Meeting of the Japanese Dermatological Association, Kumamoto, Japan, April 1-3, 1988.
Reprint requests to Department of Dermatology, Sapporo Medical College, Minami 1, Nishi 16, Sapporo 060, Japan (Dr Ito).
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