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Response of Black and White Guinea Pig Skin to Photodynamic Treatment Using 514-nm Light and Dihematoporphyrin Ether
Eric F. Bernstein, MD;
Gunter F. Thomas;
Paul D. Smith, PhD;
James B. Mitchell, PhD;
Eli Glatstein, MD, PhD;
Gary R. Kantor, MD;
Richard L. Spielvogel, MD;
Susan C. Maiese, MD;
Angelo Russo, MD, PhD
Arch Dermatol. 1990;126(10):1303-1307.
Abstract
• Differences in skin pigmentation may significantly affect light penetration during photodynamic therapy. This study evaluated the effect of skin pigmentation on dermatotoxic reaction to photodynamic therapy utilizing the photosensitizer dihematoporphyrin ether. Black and white guinea pigs were given 10 mg/kg of dihematoporphyrin ether, depilated, and treated 48 hours after injection with 30 mW/cm2 of 514-nm light. Eschar formation was observed on white skin at an average light dose of 26 J/cm2, whereas black skin showed similar changes at 58 J/cm2. Microscopically, superficial necrosis corresponded to the gross changes noted. Our results agree with data describing the difficulty of treating pigmented lesions such as malignant melanoma with photodynamic therapy. This further suggests that higher light doses may be required to treat superficial lesions and produce skin photosensitivity in dark-skinned individuals.
(Arch Dermatol. 1990;126:1303-1307)
Author Affiliations
From the Radiation Oncology Branch, National Cancer Institute (Drs Bernstein, Mitchell, Glatstein, and Russo and Mr Thomas), and the Bioengineering Division, National Institutes of Health (Dr Smith), Bethesda, Md; and the Division of Dermatology (Drs Bernstein, Kantor, and Spielvogel) and the Department of Pathology (Dr Maiese), Hahnemann University School of Medicine, Philadelphia, Pa.
Footnotes
Accepted for publication May 1, 1990.
Reprint requests to Division of Dermatology, Hahnemann University School of Medicine, Broad and Vine, M.S. 401, Philadelphia, PA 19102 (Dr Bernstein).
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