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Annemette Oxholm, MD; Peter Oxholm, MD; Flemming da Cunha Bang, MD; David F. Horrobin, MD

Arch Dermatol. 1990;126(10):1308-1311.

Abstract
• Fatty acid levels in plasma and erythrocyte cell membranes were determined in 13 Danish patients with Darier's disease and 21 Danish controls. Concentrations of the main dietary essential fatty acids, linoleic acid (18:2n-6) and -linolenic acid (18:3n-3), were consistently modestly above normal; concentrations of the 6-desaturase metabolites of both linoleic and -linolenic acids, however, were consistently and often significantly below normal. These results suggest that the capacity of the enzyme 6-desaturase activity is inadequate in patients with Darier's disease.

(Arch Dermatol. 1990;126:1308-1311)

Author Affiliations
From the Departments of Dermatology (Dr A. Oxholm) and Dentistry (Dr P. Oxholm), University of California, San Francisco; the Department of Dermatology, Bispebjerg (Denmark) Hospital (Dr da Cunha Bang); and the Efamol Research Institute, Kentville, Canada (Dr Horrobin). Dr A. Oxholm is now with the Department of Dermatology; Bispebjerg (Denmark) Hospital.

Footnotes
Accepted for publication April 24, 1990.

Reprint requests to Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke, DK-2400 NV, Denmark (Dr A. Oxholm).

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