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Nouha Domloge-Hultsch, MD; LCDR Lynn Utecht, MC; LTC(P) William James, MC; Kim B. Yancey, MD

Arch Dermatol. 1990;126(10):1337-1341.

Abstract
• Two patients demonstrating the typical clinical, histologic, and immunopathologic features of nonscarring localized bullous pemphigoid are described. These patients possess circulating IgG autoantibodies that bind the epidermal side of 1.0-mol/L sodium chloride—split human skin in indirect immunofluorescence microscopy. Immunoprecipitation studies demonstrate that these patients have circulating autoantibodies that immunoprecipitate the same 230-kd bullous pemphigoid antigen that is precipitated by autoantibodies from patients with generalized bullous pemphigoid. These findings indicate that localized bullous pemphigoid is a true clinical variant of generalized pemphigoid rather than a separate nosologic entity.

(Arch Dermatol. 1990;126:1337-1341)

Author Affiliations
USN; USA

From the Department of Dermatology, Uniformed Services University of the Health Sciences, Bethesda, Md (Drs Domloge-Hultsch and Yancey); the Department of Dermatology, National Naval Medical Center, Bethesda, Md (LCDR Utecht); and the Dermatology Service, Walter Reed Army Medical Center, Washington, DC (LTC(P) James).

Footnotes
Accepted for publication June 12, 1990.

The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of Defense or the Uniformed Services University of the Health Sciences.

Reprint requests to Department of Dermatology, B4080, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814-4799 (Dr Yancey).

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