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Electron Microscopic Study of the Skin Lesion

Naoya Shimizu, MD, PhD; Masaaki Ito, MD; Kaoru Ito, MD, PhD; Amane Nakamura, MD; Yoshio Sato, MD; Tomohiro Maruyama, MD

Arch Dermatol. 1990;126(10):1342-1346.

Abstract
• The plantar hyperkeratotic skin lesion in a case of Richner-Hanhart's syndrome was investigated using ultrastructural examination. Light microscopic examination showed remarkable hyperkeratosis and some aberrant keratinocytes with multiple nuclei. On ultrastructural examination, some abnormal structures were seen in the affected keratinocytes: aggregations of tonofilaments and intracytoplasmic inclusions. The inclusions were needle shaped and were considered to be "crystal ghosts," presumably of tyrosine. The formation of tyrosine crystalline inclusions seems to be an important factor in the pathogenesis of the cutaneous lesions in Richner-Hanhart's syndrome.

(Arch Dermatol. 1990;126:1342-1346)

Author Affiliations
From the Departments of Dermatology, Niigata (Japan) University School of Medicine (Drs Shimizu, M. Ito, K. Ito, Nakamura, and Sato) and Toyama (Japan) Medical and Pharmaceutical University (Dr Maruyama).

Footnotes
Accepted for publication May 7, 1990.

Reprints not available.

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