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Demonstration of Human Papillomavirus in Plantar Epidermoid Cysts

Kiyofumi Egawa, MD; Youichi Inaba, MD; Tomomichi Ono, MD; Tatsuyoshi Arao, MD

Arch Dermatol. 1990;126(12):1599-1603.

Abstract
• Fourteen cases of plantar epidermoid cyst were studied immunohistochemically and five of them were also studied electron microscopically for the presence of human papillomavirus. In eleven cases, the test results were positive for papillomavirus antigens, and in five of them, papillomaviruslike particles were observed by electron microscopy. Histological examination showed most of the cysts to contain intracytoplasmic eosinophilic bodies in cells of the cyst wall as well as the vacuolar structures in the keratinous mass within the cavity. These findings suggest an etiologic association between the papillomavirus and plantar epidermoid cysts. The "cystic papilloma" produced in rabbits by the Shope papillomavirus has been clearly demonstrated. We propose that human papillomaviruses play an important role in the genesis of plantar epidermoid cysts. This is the first report on the possible existence of a cystic papilloma in humans.

(Arch Dermatol. 1990;126:1599-1603)

Author Affiliations
From the Department of Dermatology, Kumamoto (Japan) University Medical School. Dr Egawa is now with the German Cancer Research Center, Institute for Virus Research, Heidelberg, Federal Republic of Germany.

Footnotes
Accepted for publication July 9, 1990.

Reprint requests to German Cancer Research Center, Institute for Virus Research, Neuenheimer Feld 506, D-6900 Heidelberg 1, Federal Republic of Germany (Dr Egawa).

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