 |
|
CyclosporineAn Immunosuppressant Affecting Epithelial Cell Proliferation
Jean Kanitakis, MD;
Jean Thivolet, MD
Arch Dermatol. 1990;126(3):369-375.
Abstract
| |
• Cyclosporine (cyclosporin A) is an immunosuppressant that selectively acts on the CD4+ subset of T lymphocytes. Recent results of experimental in vitro and in vivo studies, as well as evidence obtained through the clinical use of cyclosporine in humans, strongly suggest that cyclosporine may exert a direct effect on the growth of several epithelial cell types. Thus, cyclosporine, while stimulating the growth of hair follicle keratinocytes with a resulting hypertrichosis, appears to exert a cytostatic effect on several epithelial cell types of human and animal origin. This antiproliferative effect is shared by some minimally immunosuppressive or nonimmunosuppressive cyclosporine analogues, suggesting that the molecular mechanisms that modulate epithelial cell growth differ from those responsible for immunosuppression. This newly discovered pharmacologic property of cyclosporine may hopefully lead to the wider use of nonimmunosuppressive cyclosporines in the treatment of hyperproliferative epidermal diseases.
(Arch Dermatol. 1990;126:369-375)
Author Affiliations
From the INSERM U 209, Clinique Dermatologique, Hôpital Ed. Herriot, Lyon, France.
Footnotes
Accepted for publication September 28, 1989.
Reprint requests to INSERM U 209, Clinique Dermatologique, Hôpital Ed. Herriot, 69437 Lyon, France (Dr Kanitakis).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Drug points: Erythromelalgia induced by possible calcium channel blockade by ciclosporin
Thami and Bhalla
BMJ 2003;326:910-910.
FULL TEXT
|
