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Elastolytic Cutaneous Lesions in Myeloma-Associated Amyloidosis
Kozo Yoneda, MD;
Tadashi Kanoh, MD;
Shigeo Nomura, MD;
Motoaki Ozaki, MD;
Sadao Imamura, MD
Arch Dermatol. 1990;126(5):657-660.
Abstract
• Elastolytic cutaneous lesions were the initial manifestation of amyloidosis in two patients with multiple myeloma. The skin of the fingertip was noticeably soft, loose, and redundant. The skin of the fingers was depressed with pressure and remained depressed for an abnormally long period of time. Amyloid deposition in the dermis was demonstrated in both cases. In addition, fragmentation and a decrease of elastic fibers in the dermis were observed. Possible explanations for the pathogenesis of such skin lesions were also discussed.
(Arch Dermatol. 1990;126:657-660)
Author Affiliations
From the Departments of Dermatology (Drs Yoneda and Imamura) and Internal Medicine (Dr Kanoh), Kyoto (Japan) University, and the Departments of Internal Medicine (Dr Nomura) and Dermatology (Dr Ozaki), Hyogo Prefectural Amagasaki (Japan) Hospital.
Footnotes
Accepted for publication November 2, 1989.
Reprint requests to Department of Dermatology, Faculty of Medicine, Kyoto University, 54 Shogoin-Kawaracho, Sakyo, Kyoto 606, Japan (Dr Yoneda).
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