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The Genetics of PsoriasisHaplotype Sharing in Siblings With the Disease
Maria E. Suarez-Almazor, MD, MSc;
Anthony S. Russell, FRCP, FRCPC
Arch Dermatol. 1990;126(8):1040-1042.
Abstract
• The purpose of this study was to determine whether the inheritance of psoriasis is HLA linked. We studied 12 families with at least two siblings with psoriasis. We used a sib pair analysis comparing the HLA haplotypes in affected siblings of these families. Haplotype sharing was analyzed in 15 sib pairs; expected frequencies of haplotype sharing were estimated as 25% for HLA identity and 50% for haplotype identity. All sib pairs shared at least one haplotype and 13 of the 15 were HLA identical, compared with the expected frequency of four. These results subgest that at least one, and probably more, HLA-linked genes are implicated in the development of psoriasis.
(Arch Dermatol. 1990;126:1040-1042)
Author Affiliations
From the Rheumatic Disease Unit, University of Alberta, Edmonton, Canada.
Footnotes
Accepted for publication December 15, 1989.
Reprint requests to Rheumatic Disease Unit, 562 Heritage Medical Research Bldg, University of Alberta, Edmonton, Alberta, Canada T6G 2S2 (Dr Russell).
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