This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (13)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Clinical Manifestation of Spongiotic Inflammation of the Nail Matrix

Suthep Jerasutus, MD; Pichit Suvanprakorn, MD; Orawan Kitchawengkul, MD

Arch Dermatol. 1990;126(8):1068-1070.

Abstract
Twenty-nail dystrophy is a distinctive pattern of nail changes, in which all 20 nails are uniformly affected with excessive longitudinal ridging and loss of luster. Because of the rarity of this disorder, and controversy surrounding its cause and pathogenesis, we share our experience with five patients whose clinical diagnoses were consistent with 20-nail dystrophy. Histologically, all patients showed distinctive changes of spongiotic inflammation of the nail matrix. The cause and pathogenesis of these changes are still unknown. We suggest the concept that they represent a subgroup of endogenous eczema with a predilection for the nail matrix. A second, and less likely, hypothesis is that these lesions represent an autoimmunologic response to the nail matrix.

(Arch Dermatol. 1989;126:1068-1070)

Author Affiliations
From the Lions Suphannahong Dermatology Clinic (Dr Jerasutus), the Unit of Dermatology, Department of Medicine, Chulalongkorn Hospital (Dr Suvanprakorn), and the Bhumipol Royal Thai Air Force Hospital, Donmueng (Dr Kitchawengkul), Bangkok, Thailand.

Footnotes
Accepted for publication September 5, 1989.

Reprint requests to Lions Suphannahong Dermatology Clinic, 888/45 Ploenchit Rd, Bangkok 10500, Thailand (Dr Jerasutus).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Twenty-nail Dystrophy of Childhood with Koilonychia
Crosby et al.
CLIN PEDIATR 1991;30:117-119.