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Kazuhiko Takehara, MD, PhD; Yoshihisa Nojima, MD, PhD; Kanako Kikuchi, MD; Atsuyuki Igarashi, MD; Yoshinao Soma, MD; Tetsuya Tsuchida, MD, PhD; Yasumasa Ishibashi, MD, PhD

Arch Dermatol. 1990;126(9):1184-1186.

Abstract
• Three patients with systemic lupus erythematosus had positive antiribosomal P protein antibodies. The patients are women who had mild diseases that did not involve prominent internal organs. By using an immunofluorescence method for the detection of antinuclear antibodies that employs HEp-2 cells, these serum samples produced intense stainings on cytoplasm and nucleoli that were digested with RNase. With the use of an immunoblotting technique, these serum samples recognized three ribosomal P proteins, called PO (38 kd), P1 (19 kd), and P2 (17 kd). We suggest that antiribosomal P protein antibodies can be detected in patients with systemic lupus erythematosus and associated mild clinical features.

(Arch Dermatol. 1990;126:1184-1186)

Author Affiliations
From the Department of Dermatology (Drs Takehara, Kikuchi, Igarashi, Soma, Tsuchida, and Ishibashi) and the Third Department of Internal Medicine (Dr Nojima), University of Tokyo (Japan).

Footnotes
Accepted for publication April 18, 1990.

Reprint requests to Department of Dermatology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan (Dr Takehara).

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