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Relationship to Systemic Polyarteritis Nodosa and to Hepatitis B Infection

Gerald Minkowitz, MD; Bruce R. Smoller, MD; N. Scott McNutt, MD

Arch Dermatol. 1991;127(10):1520-1523.

Abstract
• Benign cutaneous polyarteritis nodosa has been described as having a benign course in contrast to that of systemic classic polyarteritis nodosa. We tested the hypothesis that this histologic distinction is false by reviewing nine consecutive cases with the histologic diagnosis of benign cutaneous polyarteritis nodosa. Our study revealed that on follow-up, seven (78%) of nine cases had evidence of involvement of at least one organ other than the skin, with the kidney being the organ most commonly involved. Four (44%) of nine patients had serologic evidence of hepatitis B infection, one had cryoglobulinemia, and one had polyclonal hypergammaglobulinemia associated with acquired immunodeficiency syndrome. We conclude that benign cutaneous polyarteritis nodosa is not necessarily benign and is closely related to systemic polyarteritis nodosa.

(Arch Dermatol. 1991;127:1520-1523)

Author Affiliations
From the Dermatopathology Division, Departments of Pathology and Medicine, The New York Hospital—Cornell University Medical Center, New York. Dr Smoller is now with the Dermatopathology Division, Departments of Pathology and Medicine, Stanford University School of Medicine, Palo Alto, Calif.

Footnotes
Accepted for publication May 2, 1991.

Read before the annual meeting of the United States and Canadian Academy of Pathology, March 19, 1991, Chicago, Ill.

Reprint requests to the Department of Pathology, New York Hospital, Cornell University Medical Center, 1300 York Ave, New York, NY 10021 (Dr McNutt).

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