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Duane J. Lichtenwald, MD, FRCPC; Henry R. Jakubovic, MD, FRCPC; Donald Rosenthal, MD, FRCPC

Arch Dermatol. 1991;127(10):1545-1548.

Abstract
• An unusual adult case of Langerhans cell histiocytosis is presented. The case initially mimicked granuloma annulare, both clinically and histologically. The patient subsequently had development of extensive cutaneous involvement that pathologically revealed a diffuse infiltrate of CD1-positive histiocytic cells containing Langerhans granules. Extensive investigations failed to detect systemic involvement. The patient's cutaneous eruption did not respond to various therapeutic interventions, including phototherapy with oral psoralen with long-wave UV radiation in the A range (PUVA) and systemic vinblastine sulfate. Marked but temporary clinical and histologic improvement was achieved with total body electron beam radiotherapy. The nosology of this case is discussed in the context of the various histiocytic proliferative disorders.

(Arch Dermatol. 1991;127:1545-1548)

Author Affiliations
From the Department of Medicine, Division of Dermatology (Drs Lichtenwald and Rosenthal), and the Department of Pathology (Dr Jakubovic), McMaster University, Hamilton, Ontario.

Footnotes
Accepted for publication June 17, 1991.

Reprint requests to Department of Medicine, Division of Dermatology, McMaster University, 1200 Main St W, Room 3V47, Hamilton, Ontario, Canada L8N 3Z5 (Dr Rosenthal).

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