This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (30)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Another Clinical Simulator of Kaposi's Sarcoma

Luis Requena, MD; Evaristo Sánchez Yus, MD; Lucia Martín, MD; Antonio Barat, MD; Dolores Arias, MD

Arch Dermatol. 1991;127(12):1819-1822.

Abstract
• Several types of vasculitis have been described in patients with human immunodeficiency virus infection. Erythema elevatum diutinum is a rare variant of cutaneous leukocytoclastic vasculitis which, with the exception of the case reported herein, has been described only once in human immunodeficiency virus-infected patients.

Our male patient, a longtime intravenous drug abuser, had cutaneous lesions, closely resembling Kaposi's sarcoma, on the extensor surfaces of the lower extremities. Cutaneous biopsy specimens, however, demonstrated leukocytoclastic vasculitis with fibrinoid necrosis of the vessel walls and areas of basophilic degeneration of collagen bundles in early lesions, whereas late lesions showed dense diffuse fibrosis with proliferation of dermal spindle cells and some foci of residual leukocytoclastic vasculitis. Oral therapy with dapsone resulted in marked clearing of the cutaneous lesions within few days.

This case raises the necessity of histologic confirmation for all cases of suspected Kaposi's sarcoma in patients with acquired immunodeficiency syndrome. We discuss the possible pathogenesis of leukocytoclastic vasculitis in human immunodeficiency virus-infected patients.

Author Affiliations
From the Departments of Dermatology (Drs Requena, Martín, and Arias) and Pathology (Dr Barat), Jiménez Díaz Foundation, Nuestra Señora de la Concepción Clinic, Universidad Autónoma, and the Department of Dermatology (Dr) Sánchez Yus), San Carlos University Hospital, Complutense University, Madrid, Spain.

Footnotes
Accepted for publication June 4,1991.

Reprint requests to C/ Leopoldo Alas Clarin 4-6 F, 28035 Madrid, Spain (Dr Requena).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

The HIV-positive skin biopsy
Grayson
J. Clin. Pathol. 2008;61:802-817.
ABSTRACT | FULL TEXT  

Erythematous Nodules in a Patient Infected With the Human Immunodeficiency Virus
Soni et al.
Arch Dermatol 1998;134:231-236.
FULL TEXT