Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis: A Unique Dermatosis Associated With Advanced Human Immunodeficiency Virus Infection

doi:10.1001/archderm.1991.01680020074008

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 127 No. 2, February 1991

Online Only
	•	Online First Table of Contents

STUDIES

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (129)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis

A Unique Dermatosis Associated With Advanced Human Immunodeficiency Virus Infection

David Rosenthal, MD; Philip E. LeBoit, MD; Lesley Klumpp; Timothy G. Berger, MD

Arch Dermatol. 1991;127(2):206-209.

Abstract

• We studied 13 patients with human immunodeficiency virus(HIV) infection and a chronic pruritic folliculitis that wasunresponsive to systemic treatment with bactericidal antistaphylococcalantibiotics. The skin eruption was characterized by multipleurticarial follicular papules scattered on the trunk (100%),the head and neck (85%), and the proximal aspect of the extremities(62%). Absolute peripheral eosinophil counts were increasedin six of 13 patients; a relative peripheral eosinophilia waspresent in 10 of 13 patients. Serum IgE levels were elevatedin all seven patients tested (range, 88 to 9050 IU). Histopathologicfeatures included a folliculitis with eosinophils. Pathogenicbacteria were not consistently found by routine bacterial skincultures, cultures of skin biopsy specimens, or histopathologicevaluation. CD4 counts were decreased in all of the 12 patientstested (<300 cells per cubic millimeter) and were below 250cells per cubic millimeter in 10 patients. A clinical responsewas noted to astemizole, to ultraviolet light in the B range,and to topical clobetasol propionate. These observations demonstratethat HIV-associated eosinophilic folliculitis is a unique HIV-relatedcutaneous disorder that is characterized by a culture-negative,chronic, pruritic folliculitis and a characteristic histopathologicpicture. Of special importance, because it is associated withCD4 counts of less than 250 to 300 cells per cubic millimeter,eosinophilic folliculitis appears to be an important clinicalmarker of HIV infection and, particularly, of patients at increasedrisk of developing opportunistic infections. We suggest thatthe term eosinophilic pustular folliculitis (Ofuji's disease),previously used to describe this dermatosis in HIV-infectedpatients, should be discarded.

(Arch Dermatol. 1991;127:206-209)

Author Affiliations

From the Departments of Dermatology (Drs Rosenthal, LeBoit, and Berger and Mr Klumpp) and Pathology (Dr LeBoit), University of California School of Medicine, San Francisco.

Footnotes

Accepted for publication September 5, 1990.

Reprint requests to Department of Pathology, 501 Health SciencesW, University of California School of Medicine, San Francisco,CA 94143-0506 (Dr LeBoit).

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Topical Tacrolimus for Effective Treatment of Eosinophilic Folliculitis Associated With Human Immunodeficiency Virus Infection
Toutous-Trellu et al.
Arch Dermatol 2005;141:1203-1208.
FULL TEXT

Eosinophilic Folliculitis: Before and After the Introduction of Antiretroviral Therapy
Rajendran et al.
Arch Dermatol 2005;141:1227-1231.
ABSTRACT | FULL TEXT

Eosinophilic Folliculitis in 2 HIV-Positive Women
Arch Dermatol 2004;140:463-465.

Granuloma Annulare: A Mucocutaneous Condition in Human Immunodeficiency Virus-Infected Patients
Cohen
Arch Dermatol 1999;135:1404-1407.
FULL TEXT

Hormone-Induced Acneiform Eruption in Human Immunodeficiency Virus Disease
Kwon et al.
Arch Dermatol 1998;134:374-376.
FULL TEXT

Isotretinoin Treatment of Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis: Results of an Open, Pilot Trial
Otley et al.
Arch Dermatol 1995;131:1047-1050.
ABSTRACT

Metronidazole for Eosinophilic Pustular Folliculitis in Human Immunodeficiency Virus Type 1-Positive Patients
Smith et al.
Arch Dermatol 1995;131:1089-1091.
ABSTRACT

Itraconazole Therapy for Human Immunodeficiency Virus-Associated Eosinophilic Folliculitis
Berger et al.
Arch Dermatol 1995;131:358-360.
ABSTRACT

Eosinophilic Folliculitis Associated With the Acquired Immunodeficiency Syndrome Responds Well to Permethrin
Blauvelt et al.
Arch Dermatol 1995;131:360-361.
ABSTRACT

Lichenoid Photoeruptions in Human Immunodeficiency Virus Infection
Berger and Dhar
Arch Dermatol 1994;130:609-613.
ABSTRACT

Eosinophilic Pustular Folliculitis (Ofuji's Disease) Immunohistochemical Analysis
Teraki et al.
Arch Dermatol 1993;129:1015-1019.
ABSTRACT

Eosinophilic Pustular Folliculitis in Infancy and Childhood
Duarte et al.
Arch Pediatr Adolesc Med 1993;147:197-200.
ABSTRACT

Primary Cutaneous Aspergillosis Near Central Venous Catheters in Patients With the Acquired Immunodeficiency Syndrome
Hunt et al.
Arch Dermatol 1992;128:1229-1232.
ABSTRACT

Cutaneous Manifestations of Human Immunodeficiency Virus Infection: Part II
Dover and Johnson
Arch Dermatol 1991;127:1549-1558.
ABSTRACT

Dermatology
Dover and Arndt
JAMA 1991;265:3111-3113.
ABSTRACT

| | |