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Steven S. Greenbaum, MD; John Varga, MD

Arch Dermatol. 1991;127(2):231-233.

Abstract
• Long-term treatment with high doses of corticosteroids leads to the development of truncal obesity and focal fatty deposition. These deposits characteristically are located on the face, the nuchal and truncal areas, and episternally, as well as in the mediastinum and epicardium. We studied a patient with juxta-articular adiposis dolorosa who had L-tryptophan-associated eosinophilia-myalgia syndrome and was treated with high doses of prednisone. This is the first reported case of adiposis dolorosa occurring as a complication of corticosteroid treatment. Alterations of fat metabolism induced by corticosteroid excess may have played a role in the development of this unusual painful syndrome.

(Arch Dermatol. 1991;127:231-233)

Author Affiliations
From the Departments of Dermatology (Dr Greenbaum) and Medicine (Dr Varga), Jefferson Medical College, Philadelphia, Pa.

Footnotes
Accepted for publication October 22, 1990.

Reprint requests to Department of Dermatology, Thomas Jefferson University, Suite 4019, 111 S 11th St, Philadelphia, PA 19107 (Dr Greenbaum).

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