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Demonstration of Autoantibodies That Bind to Both the Pemphigus Foliaceus Antigen Complex and the Bullous Pemphigoid Antigen

Neil J. Korman, PhD, MD; John R. Stanley, MD; David T. Woodley, MD

Arch Dermatol. 1991;127(3):387-390.

Abstract
• Pemphigus and bullous pemphigoid are autoimmune blistering diseases of the skin characterized by circulating autoantibodies directed against the keratinocyte cell surface and the epidermal basement membrane zone, respectively. The coexistence of pemphigus and bullous pemphigoid is very uncommon. We describe a patient with pemphigus foliaceus who later developed bullous pemphigoid and show, by means of immunoprecipitation studies utilizing both cultured keratinocytes and suction blister epidermis, that our patient had circulating autoantibodies directed against both the pemphigus foliaceus antigen complex and the bullous pemphigoid antigen. This report is the first to demonstrate the coexistence of pemphigus foliaceus and bullous pemphigoid at the molecular level.

(Arch Dermatol. 1991;127:387-390)

Author Affiliations
From the Dermatology Branch, National Cancer Institute, Bethesda, Md (Drs Korman and Stanley), and the Department of Dermatology, University of North Carolina, Chapel Hill (Dr Woodley). Dr Woodley is now with the Department of Dermatology, Stanford (Calif) University, and Dr Korman is with the Department of Dermatology, Case Western Reserve University, Cleveland, Ohio.

Footnotes
Accepted for publication October 10, 1990.

Reprint requests to Department of Dermatology, Case Western Reserve University, 2074 Abington Rd, Cleveland, OH 44106 (Dr Korman).

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