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  Vol. 127 No. 3, March 1991 TABLE OF CONTENTS
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Coexistence of pemphigus foliaceus and bullous pemphigoid. Demonstration of autoantibodies that bind to both the pemphigus foliaceus antigen complex and the bullous pemphigoid antigen

N. J. Korman, J. R. Stanley and D. T. Woodley
Dermatology Branch, National Cancer Institute, Bethesda, Md.

Pemphigus and bullous pemphigoid are autoimmune blistering diseases of the skin characterized by circulating autoantibodies directed against the keratinocyte cell surface and the epidermal basement membrane zone, respectively. The coexistence of pemphigus and bullous pemphigoid is very uncommon. We describe a patient with pemphigus foliaceus who later developed bullous pemphigoid and show, by means of immunoprecipitation studies utilizing both cultured keratinocytes and suction blister epidermis, that our patient had circulating autoantibodies directed against both the pemphigus foliaceus antigen complex and the bullous pemphigoid antigen. This report is the first to demonstrate the coexistence of pemphigus foliaceus and bullous pemphigoid at the molecular level.

RELATED LETTER

Clinical Evidence of an Intermolecular Epitope Spreading in a Patient With Pemphigus Foliaceus Converting Into Bullous Pemphigoid
Jennifer D. Peterson, Agnes J. Chang, and Lawrence S. Chan
Arch Dermatol. 2007;143(2):272-274.
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Clinical Evidence of an Intermolecular Epitope Spreading in a Patient With Pemphigus Foliaceus Converting Into Bullous Pemphigoid
Peterson et al.
Arch Dermatol 2007;143:272-274.
FULL TEXT  





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