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A Multicenter Study

Gerald D. Weinstein, MD; Thomas P. Nigra, MD; Peter E. Pochi, MD; Ronald C. Savin, MD; Anne Allan, MD; Karen Benik, MD; Edward Jeffes, MD, PhD; Laura Lufrano, MS; E. George Thorne, MD

Arch Dermatol. 1991;127(5):659-665.

Abstract
• The clinical and histologic effects of a new emollient cream formulation of topical tretinoin at concentrations of 0.05% and 0.01% were examined in 251 subjects with mild to moderate photodamaged facial skin in a randomized, doubleblind, vehicle-controlled, multicenter study. Seventy-nine percent of the subjects who received 0.05% tretinoin for 24 weeks showed overall improvement in photodamaged skin compared with improvement in 48% of the vehicle-treated control subjects. Significant reductions were found in fine wrinkling, mottled hyperpigmentation, roughness, and laxity after 0.05% tretinoin therapy when compared with controls. In addition, histologic changes of increased epidermal thickness, decreased melanin content, and stratum corneum compaction provide independent evidence supporting clinical improvement. Side effects of erythema, peeling, and stinging were usually mild and well tolerated.

(Arch Dermatol. 1991;127:659-665)

Author Affiliations
From the Department of Dermatology, University of California at Irvine (Drs Weinstein, Benik, and Jeffes); the Washington (DC) Hospital Center (Dr Nigra); the Boston (Mass) University School of Medicine (Drs Pochi and Allan); Adult and Adolescent Dermatology, PC, New Haven, CT (Dr Savin); and R. W. Johnson Pharmaceutical Research Institute, Raritan, NJ (Dr Thorne and Ms Lufrano).

Footnotes
Accepted for publication January 17, 1991.

Read in part before the Annual Meeting of the American Academy of Dermatology, San Francisco, Calif, December 3, 1989.

Reprint requests to the Department of Dermatology, University of California at Irvine, Irvine, CA 92717 (Dr Weinstein).

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