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Interleukin 1 , Tumor Necrosis Factor , and Interferon  in Psoriasis
Toshihiko Gomi, MD;
Tetsuo Shiohara, MD, PhD;
Takako Munakata;
Ken'ichi Imanishi, PhD;
Masaji Nagashima, MD, PhD
Arch Dermatol. 1991;127(6):827-830.
Abstract
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• Although recent studies have suggested that a variety of cytokines released by keratinocytes and inflammatory leukocytes could contribute to induction or persistence of the inflammatory processes in psoriasis, it remains unclear how production of these cytokines is regulated in psoriatic patients. To elucidate the biologic relevance of these cytokines to the pathogenesis of psoriasis, we investigated serum levels of interleukin 1 , tumor necrosis factor , and interferon  in 21 patients with psoriasis vulgaris, together with 21 healthy controls. The mean serum levels of interleukin 1 and tumor necrosis factor were not significantly different from those in controls, while those of interferon were significantly elevated in the patients with psoriasis. Serum levels of interleukin 1 correlated negatively with clinical disease severity expressed as psoriasis area and severity index score and with duration of psoriasis. In contrast, interferon levels were related, although not significantly, to disease severity. In addition, an inverse correlation was noted between the interleukin 1 levels and interferon levels. These results indicate that interleukin 1 and interferon may be relevant to the induction and perpetuation, respectively, of the inflammatory responses in psoriasis, and that these cytokines, which have similar biologic properties, may strictly regulate one another's production in vivo.
(Arch Dermatol. 1991;127:827-830)
Author Affiliations
From the Department of Dermatology, Kyorin University School of Medicine (Drs Gomi, Shiohara, and Nagashima), the Institute of Kohtohbiken Tohoku Special Analysis Laboratories (Ms Munakata), and the Department of Microbiology, Tokyo Women's Medical College (Dr Imanishi), Tokyo, Japan.
Footnotes
Accepted for publication January 4, 1991.
Reprint requests to Department of Dermatology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, 181 Tokyo, Japan (Dr Shiohara).
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