 |
|
Immunoblot Assay as an Aid to the Diagnoses of Unclassified Cases of Pemphigus
Takashi Hashimoto, MD;
Akira Konohana, MD;
Takeji Nishikawa, MD
Arch Dermatol. 1991;127(6):843-847.
Abstract
• With use of an immunoblot assay for both the normal human epidermal extracts and the bovine desmosome preparation, we investigated sera from 18 patients with pemphigus, who exhibited atypical clinical or histologic features and whose diagnoses were difficult to identify. Four sera yielded a 130-kd protein band in the epidermal extracts, which is characteristic of pemphigus vulgaris. A 150-kd protein was identified by nine sera in the epidermal extracts and/or the desmosome preparation, which is known as a pemphigus foliaceus antigen. Five sera demonstrated neither antigen. These results suggest that the immunoblot technique is useful to distinguish pemphigus vulgaris from pemphigus foliaceus and can be a good tool for the diagnosis of pemphigus, especially unclassified cases.
(Arch Dermatol. 1991;127:843-847)
Author Affiliations
From the Department of Dermatology, Keio University School of Medicine, Tokyo, Japan.
Footnotes
Accepted for publication December 24, 1990.
Reprint requests to the Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160, Japan (Dr Hashimoto).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Endemic Pemphigus Vulgaris
Rocha-Alvarez et al.
Arch Dermatol 2007;143:895-899.
ABSTRACT
| FULL TEXT
Changes in Clinical Features, Histologic Findings, and Antigen Profiles With Development of Pemphigus Foliaceus From Pemphigus Vulgaris
Kawana et al.
Arch Dermatol 1994;130:1534-1538.
ABSTRACT
|
