 |
|
Transforming Growth Factor  Expression Helps to Distinguish Keratoacanthomas From Squamous Cell Carcinomas
Tony Ho, MD;
Thomas Horn, MD;
Eric Finzi, MD, PhD
Arch Dermatol. 1991;127(8):1167-1171.
Abstract
• Keratoacanthomas may be difficult to distinguish histologically from squamous cell carcinomas. We studied 20 keratoacanthomas and 22 squamous cell carcinomas immunohistochemically using an antibody directed against transforming growth factor  to determine if the pattern of transforming growth factor expression would provide a useful method of differentiating these tumors. Ninety percent of the keratoacanthomas demonstrated a diffuse pattern within tumor lobules in which all but the most peripheral rim of cells were stained. A similar localization of transforming growth factor was not identified in squamous cell carcinomas. In addition, 40% of the squamous cell carcinomas but none of the keratoacanthomas showed focal transforming growth factor immunostaining. Our results suggest that transforming growth factor expression may be a marker of epithelial differentiation and may help distinguish between these two tumors.
(Arch Dermatol. 1991;127:1167-1171)
Author Affiliations
From the Department of Dermatology, The Johns Hopkins Medical Institution, Baltimore, Md.
Footnotes
Accepted for publication March 21, 1991.
Presented at the American Dermatologic Society Meeting, Atlanta, Ga, November 30, 1990.
Reprints not available.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
PGP 9.5 and Cyclin D1 Coexpression in Cutaneous Squamous Cell Carcinomas
Mastoraki et al.
INT J SURG PATHOL 2009;17:413-420.
ABSTRACT
Differential ErbB1 Signaling in Squamous Cell versus Basal Cell Carcinoma of the Skin
Rittie et al.
Am. J. Pathol. 2007;170:2089-2099.
ABSTRACT
| FULL TEXT
p53 Oncoprotein Expression and Gene Mutations in Some Keratoacanthomas
Perez et al.
Arch Dermatol 1997;133:189-193.
ABSTRACT
|
