 |
|
Waldenström Macroglobulinemia With an IgM- Antiepidermal Basement Membrane Zone Antibody
LCDR Mark W. Cobb, MC;
Nouha Domloge-Hultsch, MD;
LCDR James N. Frame, MC;
Kim B. Yancey, MD
Arch Dermatol. 1992;128(3):372-376.
Abstract
| |
• Background.—
Waldenström macroglobulinemia, a lymphoplasmacytoid cell malignant neoplasm associated with a monoclonal IgM paraprotein, has been associated with a number of cutaneous manifestations. On rare occasions, IgM deposits have been demonstrated in the epidermal basement zone of patients with WM.
Observations.—
We report the case of a patient with Waldenström macroglobulinemia and IgM- paraprotein who had development of an eruption of pruritic papules and demonstrated the following unusual immunopathologic findings: (1) deposits of IgM- in the epidermal basement membrane zone of lesional and nonlesional skin; (2) a circulating IgM- antiepidermal basement membrane zone antibody; and (3) binding of this circulating IgM- antiepidermal basement membrane zone antibody to both sides of 1 mol/L sodium chloride split skin. The cutaneous eruption cleared completely with oral psoralen with long-wave UV radiation in the A range (PUVA) therapy.
Conclusions.—
We present a patient with Waldenström macroglobulinemia who had a distinctive papular eruption and immunopathologic findings suggesting that his paraprotein has specificity for the epidermal basement membrane zone.
(Arch Dermatol. 1992;128:372-376)
Author Affiliations
USN; USNR
From the Department of Dermatology (Dr Cobb) and the Division of Hematology-Medical Oncology, Department of Medicine (Dr Frame), National Naval Medical Center, and the Department of Dermatology, Uniformed Services University of the Health Sciences (Drs Domloge-Hultsch and Yancey), Bethesda, Md.
Footnotes
Accepted for publication September 6, 1991.
The opinions or assertions contained herein are the private ones of the authors and are not to be construed as official or reflecting the views of the Department of Defense, the Department of the Navy, or the Uniformed Services University of the Health Sciences.
Reprint requests to Department of Dermatology, National Naval Medical Center, Bethesda, MD 20889 (Dr Cobb).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Case 27-2001- A 50-Year-Old Man with Marked Splenomegaly and Anemia
Raje and Ferry
NEJM 2001;345:682-687.
FULL TEXT
Waldenstrom Macroglobulinemia-Induced Bullous Dermatosis
West et al.
Arch Dermatol 1998;134:1127-1131.
ABSTRACT
| FULL TEXT
A Paraneoplastic Mixed Bullous Skin Disease Associated With Anti-skin Antibodies and a B-Cell Lymphoma
Bystryn et al.
Arch Dermatol 1993;129:870-875.
ABSTRACT
The Significance of Linear IgM Deposits in the Basement Membrane Zone
Velthuis and de Jong
Arch Dermatol 1992;128:1653-1653.
ABSTRACT
The Significance of Linear IgM Deposits in the Basement Membrane Zone-Reply
Cobb et al.
Arch Dermatol 1992;128:1653-1653.
ABSTRACT
|
