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Immunologic Abnormalities Associated With Primary Anetoderma
Emmilia Hodak, MD;
Orna Shamai-Lubovitz, MD;
Michael David, MD;
Bilha Hazaz;
Varda Katzenelson-Weissman, MD;
Meir Lahav, MD;
Miriam Sandbank, MD
Arch Dermatol. 1992;128(6):799-803.
Abstract
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• Background and Design.—
Primary anetoderma is a rare cutaneous elastolytic disorder, the etiopathogenesis of which has not yet been established. Six patients with primary anetoderma were studied in an attempt to assess the role of the immunologic system in the elastolytic process. The investigation included the medical history, physical examination, routine blood tests, specific tests for collagen diseases, prothrombin time, activated partial thromboplastin time, thyroxine, indirect immunofluorescence test, and skin biopsies for histopathologic study and direct immunofluorescence.
Results.—
Two of the patients presented with autoimmune disorders: the first had Graves' disease, lupus anticoagulant, and autoimmune hemolysis, and the second had systemic scleroderma. There were positive direct immunofluorescence findings in most of the patients. Furthermore, all of them were found to have serologic immunologic abnormalities, of which the most common was a positive antinuclear factor.
Conclusions.—
These findings indicate that there is an immunologic involvement in primary anetoderma.
(Arch Dermatol. 1992;128:799-803)
Author Affiliations
From the Departments of Dermatology (Drs Hodak, Shamia-Lubovitz, David, Katznelson-Weissman, and Sandbank), Pathology (Ms Hazaz), and Internal Medicine E (Dr Lahav), Beilinson Medical Center, Petah Tiqva, Sackler School of Medicine, Tel Aviv University, Israel.
Footnotes
Accepted for publication December 2, 1991.
Reprint requests to Department of Dermatology, Beilinson Medical Center, Petah Tiqva 49100, Israel (Dr Hodak).
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