This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (26)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Differential Response to Therapy

Herschel S. Zackheim, MD; Philip E. LeBoit, MD; Bernard I. Gordon, MD; Alan B. Glassberg, MD

Arch Dermatol. 1993;129(1):86-91.

Abstract
• Background.—
The association of lymphomatoid papulosis (LyP) with Hodgkin's lymphoma or other lymphomas is well recognized. However, the issue as to whether this represents an independent association or a transformation of one proliferative process to the other remains unresolved.

Observation.—
A woman with LyP subsequently developed Hodgkin's lymphoma. Combination chemotherapy resulted in apparent cure of the lymphoma but had only a transient effect on the LyP. A literature review revealed a similar difference in response to chemotherapy or radiation therapy in most patients who had LyP and associated lymphoma.

Conclusions.—
The differential response to therapy in patients with LyP and associated lymphoma suggests that there are biological differences between LyP cells and associated lymphoma cells even though in some patients the immunophenotype and genotype were reported to be identical. However, alternative explanations are possible. In this article we also review studies on other cases of LyP associated with Hodgkin's lymphoma.

(Arch Dermatol. 1993;129:86-91)

Author Affiliations
From the Departments of Dermatology (Drs Zackheim, LeBoit, and Gordon), Pathology (Dr LeBoit), University of California, San Francisco, and Mt Zion Medical Center, San Francisco, Calif (Dr Glassberg).

Footnotes
Accepted for publication September 4, 1992.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Prognosis of Lymphomatoid Papulosis
Gruber et al.
The Oncologist 2006;11:955-957.
FULL TEXT  

Molecular Diagnosis of Lymphocytic Infiltrates of the Skin
Weinberg et al.
Arch Dermatol 1993;129:1491-1500.
ABSTRACT  

Lymphomatoid Papulosis and Associated Lymphomas: How Are They Related?
Kadin
Arch Dermatol 1993;129:351-353.
ABSTRACT