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Desipramine-Induced Blue-Gray Photosensitive Pigmentation
Vic Narurkar, MD;
Bruce R. Smoller, MD;
Chung-Hong Hu, MD;
Eugene A. Bauer, MD
Arch Dermatol. 1993;129(4):474-476.
Abstract
 Background.—
Blue-gray pigmentation of the skin can be elicited by several medications. We report the first case (to our knowledge) of desipramine-induced photosensitive blue-gray pigmentation.
Observations.—
Diffuse blue-gray pigmentation on sun-exposed surfaces was noted in a healthy 48-year-old woman who had been taking desipramine hydrochloride for 8 years. Ultrastructural studies demonstrated the presence of melanin and homogeneous electron-dense material in the dermis.
Conclusions.—
We conclude that tricyclic antidepressant agents represent another class of medications responsible for blue-gray cutaneous pigmentation.
(Arch Dermatol. 1993;129:474-476)
Author Affiliations
From the Departments of Dermatology (Drs Narurkar, Smoller, Hu, and Bauer) and Pathology (Dr Smoller), Stanford (Calif) University Medical Center.
Footnotes
Accepted for publication November 16, 1992.
Reprint requests to Department of Dermatology, Stanford University Medical Center, Stanford, CA 94305 (Dr Smoller).
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