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Precise Ablation of Skin With Reduced Collateral Damage Using the Femtosecond-Pulsed, Terawatt Titanium-Sapphire Laser
Kim S. Frederickson;
William E. White, PhD;
Ronald G. Wheeland, MD;
Dennis R. Slaughter, PhD
Arch Dermatol. 1993;129(8):989-993.
Abstract
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Background and Design
The precise ablation of skin was studied using an ultrashort-pulsed, high-intensity titanium-sapphire (Ti:Al2O3) laser capable of peak intensities of tens of terawatts (TW; 1 TW = 1012 watts [W]) per square centimeter. Rat skin was exposed in vitro to femtosecond-pulsed Ti:Al2O3 laser radiation at 800 nm, while varying the number of pulses and the intensity up to 46 TW/cm2. Ablation was evaluated by monitoring the amount of tissue removed per pulse as a function of energy, and by light microscopic examination of damage to adjacent, nonirradiated tissue.
Observations
Ablation depth per pulse was 0.1 µm at threshold intensity, and it was increased with both the energy per pulse and the number of pulses. Minimal damage to adjacent healthy tissue was observed, varying 0 to 30 µm.
Conclusion
The results suggest that ablation of skin with femtosecond-pulsed, terawatt Ti:Al2O3 laser may have potential for precision cutaneous surgery, and in vivo studies are indicated.
(Arch Dermatol. 1993;129:989-993)
Author Affiliations
From the Department of Dermatology, University of California, Davis, Sacramento (Ms Frederickson and Dr Wheeland); and Lawrence Livermore National Laboratory, University of California, Livermore (Drs White and Slaughter).
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