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Herbert Goldschmidt, MD; William K. Sherwin, MD, PhD

Arch Dermatol. 1993;129(9):1162-1165.

Abstract
Background and Design
Giant aggressive keratoacanthoma is a rare destructive subset of keratoacanthoma that frequently involves the facial region, grows rapidly to a large size, and often recurs after surgical management. The effectiveness of ionizing radiation therapy was examined in a retrospective study involving 16 patients; 14 of the tumors had recurred after surgical therapy.

Results
All tumors resolved with satisfactory cosmetic results and without recurrence following a fractionated course of superficial radiation therapy.

Conclusions
Radiation therapy is an effective therapeutic modality for giant aggressive keratoacanthomas.

(Arch Dermatol. 1993;129:1162-1165)

Author Affiliations
From the Department of Dermatology, University of Pennsylvania Medical School, Philadelphia.

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