This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Carine Jubert, MD; Jean-Michel Pawlotsky, MD; Florence Pouget, MD; Chantal Andre, PhD; Lionel DeForges; Stéphane Bretagne, MD; Jean-Philippe Mavier, MD, PhD; Jean Duval, MD; Jean Revuz, MD; Daniel Dhumeaux, MD; Martine Bagot, MD, PhD

Arch Dermatol. 1994;130(1):73-76.

Abstract
Background and Design
An increased prevalence of chronic liver disease has been reported in patients with lichen planus (LP). We report six cases of LP associated with chronic active hepatitis and actively replicating hepatitis C virus (HCV).

Results
We studied six patients (three men and three women; mean age, 61 years; age range, 47 to 70 years) with various forms (cutaneous and/or mucosal) of LP and abnormal liver test results. Four patients had severe mucosal lesions. Cutaneous and mucosal lesions had a long-term evolution. Liver disease was discovered 2 to 6 years before LP in three cases and was diagnosed at the same time as LP in the three other cases. Liver biopsy performed in five patients showed chronic active hepatitis without cirrhosis in all five cases. Anti—HCV antibodies were detected in all cases by second-generation enzyme-linked immunosorbent assay and confirmed by second-generation recombinant immunoblot assay. Hepatitis C virus RNA was evidenced by means of polymerase chain reaction in the serum samples from the six patients, proving active viral replication.

Conclusions
Lichen planus may be associated with HCV-related chronic active hepatitis. As interferon treatment may induce viral inactivation in some patients with HCV-related chronic liver disease, a search for HCV infection should be systematically performed in patients with chronic LP.

(Arch Dermatol. 1994;130:73-76)

Author Affiliations
From the Departments of Dermatology (Drs Jubert, Pouget, Revuz, and Bagot), Bacteriology and Virology (Drs Pawlotsky, DeForges, Bretagne, and Duval), Immunology (Dr Andre), and Hepatology (Drs Mavier and Dhumeaux), University of Paris XII, Créteil, France.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

ORAL DISEASES POSSIBLY ASSOCIATED WITH HEPATITIS C VIRUS
Carrozzo and Gandolfo
CROBM 2003;14:115-127.
ABSTRACT | FULL TEXT  

Decreased tear lactoferrin concentration in patients with chronic hepatitis C
Abe et al.
Br. J. Ophthalmol. 1999;83:684-687.
ABSTRACT | FULL TEXT  

Topical Tetracycline Treatment of Erosive Oral Lichen Planus
Walchner et al.
Arch Dermatol 1999;135:92-93.
FULL TEXT  

Update On Oral Lichen Planus: Etiopathogenesis and Management
Scully et al.
CROBM 1998;9:86-122.
ABSTRACT | FULL TEXT  

Oral Lichen Planus and Hepatitis C Virus Infection: A Fortuitous Association?
Dupin et al.
Arch Dermatol 1997;133:1052-1053.
ABSTRACT  

Essential Mixed Cryoglobulinemia: A Comparative Study of Dermatologic Manifestations in Patients Infected or Noninfected With Hepatitis C Virus
Dupin et al.
Arch Dermatol 1995;131:1124-1127.
ABSTRACT  

Hepatitis C Virus in Dermatology: A Review
Pawlotsky et al.
Arch Dermatol 1995;131:1185-1193.
ABSTRACT  

Cutaneous Chronic Graft-vs-Host Disease and Hepatitis C Virus
Bouloc et al.
Arch Dermatol 1995;131:853-855.
ABSTRACT  

Association of Prurigo With Hepatitis C Virus Infection
Kanazawa et al.
Arch Dermatol 1995;131:852-853.
ABSTRACT  

Lichen Planus Associated with Hepatitis C Virus
Journal Watch Dermatology 1994;1994:6-6.
FULL TEXT