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Barbara A. Gilchrest, MD; Marjan Garmyn, MD; Mina Yaar, MD

Arch Dermatol. 1994;130(1):82-86.

Abstract
Background
Aging has two components: changes that occur in all individuals with the passage of time alone and changes that occur to varying degrees in different individuals as a result of repeated environmental injury. In the skin, the major environmental influence is sun exposure, and the combined effect of aging and sun damage has been termed photoaging. To determine whether aging and photoaging have characteristic effects on gene expression, we performed Northern blot analysis of several genes in early-passage cultured keratinocytes derived from donors of different ages (newborn, young adult, and old adult) and from paired sun-exposed (photoaged) and sun-protected sites of old-adult donors.

Observations
We examined genes involved in cell division, immunomodulation, or differentiation. Aging alone strikingly increased the baseline expression of the differentiation-associated SPR2 and interleukin 1 receptor antagonist (IL-lra) genes but had relatively little effect on the UV inducibility of any genes studied. In contrast, photoaging markedly increased the inducibility of the c-fos proto-oncogene and decreased the baseline expression of SPR2 and IL-lra relative to that in cells derived from sun-protected skin of the same donors.

Conclusions
Both aging and photoaging alter the expression of selected genes that are implicated in growth, differentiation, immunomodulation, and UV response in human epidermis. This may explain, in part, the predisposition to photocarcinogenesis in chronically sunexposed skin of older individuals.

(Arch Dermatol. 1994;130:82-86)

Author Affiliations
From the Department of Dermatology, Boston (Mass) University School of Medicine.

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