E-Selectin and Vascular Cell Adhesion Molecule-1 Are Critical for Initial Trafficking of Helper-Inducer/Memory T Cells in Psoriatic Plaques
Hisashi Wakita, MD;
Masahiro Takigawa, MD
Arch Dermatol. 1994;130(4):457-463.
Abstract
Background
To better understand local migration of inflammatory cells in psoriasis, we compared immunohistochemically the expression of cell adhesion molecules on endothelial cells of papillary microvessels, a subpapillary microvessel (SPMV), with the phenotypic profile of infiltrating T cells in initial, active, and involuting psoriatic lesions.
Results
Intercellular adhesion molecule-1, E-selectin, and vascular cell adhesion molecule-1 (VCAM-1) on papillary microvessel E-selectin and VCAM-1 on SPMV that had not been detected in normal/noninvolved skin were induced in psoriatic lesions. Intercellular adhesion molecule-1 on SPMV was constitutively expressed in normal/ noninvolved skin and augmented in the degree of expression in psoriatic lesions. Intraepidermal and dermal angiocentric T cells in the initial and active lesions belonged predominantly to the CD3+, CD4+, CD45RO+, lympho
cyte function—associated antigen-1+, and very late antigen-4+ helper-inducer/memory subset. The number of these memory T cells around SPMV was significantly correlated with the degree of expression of E-selectin and VCAM-1 on SPMV in the initial lesion. Intraepidermal memory T cells in the active lesion showed significant correlation with the expression of E-selectin and VCAM-1 on PMV. The CD8+ cells were dominant in the epidermis of the involutingphase. None of the adhesion molecules studied seemed to play a role in infiltration of this cell type.
Conclusions
The results suggest (1) participation of memory T cells in the formation of the initial and active stages of psoriatic plaques, and (2) E-selectin and VCAM-1 on endothelium as the critical adhesion molecule for initial trafficking of memory T cells into psoriatic lesions.
(Arch Dermatol. 1994;130:457-463)
Author Affiliations
From the Department of Dermatology, Hamamatsu (Japan) University School of Medicine.
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