 |
|
Cutaneous Crystalline Deposits in Myeloma
Rachel E. Jenkins, BSc, MRCP;
Eduardo Calonje, MD;
Hilary Fawcett, MRCP;
Malcom W. Greaves, MD, FRCP;
Edward Wilson-Jones, FRCP, FRCPath
Arch Dermatol. 1994;130(4):484-488.
Abstract
Background
Myeloma is a plasma cell malignancy that usually presents with systemic manifestations or symptoms related to bone involvement. We describe the first case of crystalline protein deposition in the skin as the initial manifestation of myeloma.
Observations
Crystals were found mainly in the extracellular space in the dermis of both involved and uninvolved skin in the absence of plasma cell infiltration. Crystals were also found in conjunctival tissue and bone marrow.
Conclusions
We have described a unique case of myeloma that presented as facial and eyelid swelling. There were crystalline deposits in the skin and conjunetivae, but mechanisms of crystal formation and the factors causing local deposition were not established. However, treatment of the underlying disorder leads to resolution of the cutaneous features of crystal deposition.
(Arch Dermatol. 1994;130:484-488)
Author Affiliations
From the St John's Institute of Dermatology, St Thomas' Hospital, London, England (Drs Jenkins, Calonje, Greaves, and Wilson-Jones); and Basingstoke (England) District General Hospital (Dr Fawcett).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Multiple myeloma with bone marrow extracellular crystal deposition
Brodie et al.
J. Clin. Pathol. 2007;60:1064-1065.
FULL TEXT
Crystalline plasma cell inclusions in helicobacter-associated gastritis
Stewart and Spagnolo
J. Clin. Pathol. 2006;59:851-854.
ABSTRACT
| FULL TEXT
Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature
Lebeau et al.
Blood 2002;100:1817-1827.
ABSTRACT
| FULL TEXT
|
