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A Prospective Study of 3192 Pregnant Women

Denis Roger, MD; Loïc Vaillant, MD; Alain Fignon, MD; Fabrice Pierre, MD; Yannick Bacq, MD; Jean-François Brechot, MD; Marie-Claire Grangeponte, MD; Gérard Lorette, MD

Arch Dermatol. 1994;130(6):734-739.

Abstract
Background and Design
For a period of 1 year, all pregnant women presenting with itching were investigated by clinical, histologic, immunopathologic, and laboratory studies. Fifty-one of 3192 pregnant women were studied.

Results
We identified (1) two typical cases of herpes gestationis, with an approximate incidence of one in 1700 pregnancies; (2) 22 cases of pruritus gravidarum, including five cases with a polymorphous skin eruption, with an incidence of one in 145 pregnancies; (3) 25 cases of polymorphic eruption of pregnancy, including diseases without maternal or fetal side effects and without criteria defining herpes ges- tationis or pruritus gravidarum, with an incidence of one in 130 pregnancies; and (4) two cases of intercurrent disease (one scabies and one exfoliative dermatitis).

Conclusion
Our study is a prospective homogeneous account of pruritic dermatosis of pregnancy. Our results show that the incidence of herpes gestationis is higher than is usually reported in the literature and that pruritus gravidarum must be considered in the presence of itching occurring during pregnancy, with or without skin eruption.

(Arch Dermatol. 1994;130:734-739)

Author Affiliations
From the Departments of Dermatology (Drs Roger, Vaillant, and Lorette), Gastroenterology (Dr Bacq), Biochemistry (Dr Brechot), and Pathology (Dr Grangeponte), Hôpital Trousseau, and the Department of Obstretrics and Gynecology, Hôpital Bretonneau and Beffroi (Drs Fignon and Pierre), Tours, France.

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