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  Vol. 131 No. 1, January 1995 TABLE OF CONTENTS
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Possible Role of Cytokines in Cellular Proliferation of the Skin Transplanted Onto Nude Mice

Amos Gilhar, MD; Thomas Pillar, MD; Amos Etzioni, MD

Arch Dermatol. 1995;131(1):38-42.


Abstract



Background and Design
In recent studies on the behavior of aged skin transplanted onto nude mice, the epidermis of aged and young skin showed an increase in proliferation and thickness following engraftment, and became almost identical. The aim of this study was to ascertain a possible role for the release of local cytokines in this phenomenon. Grafted human skin was injected intradermally with anti—interleukin-6 (IL) and anti—IL-l{alpha}, and comparisons of epidermal thymidine incorporation and thickness were made. Grafts injected with irrelevant antibodies served as control.

Results
Interleukin-6 and IL-1{alpha} expression were studied in grafts by immunoperoxidase staining. Only IL-6 expression was found in the 1-month grafts. Intradermal injections of anti—IL-1{alpha} and anti—IL-6 showed an inhibitory effect on cellular proliferation in the epidermis. A significant difference in the response of epidermal proliferation and, consequently, in thickness was found in samples injected with anti—IL-1{alpha} and anti—IL-6 compared with those injected with irrelevant antibodies.

Conclusions
These data may indicate that local cytokines released by the keratinocytes are involved in the cellular proliferative activity in skin engrafted onto the mice.

(Arch Dermatol. 1995;131:38-42)



Author Affiliations



From the Skin Research Laboratory, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Aging of Human Epidermis: Reversal of Aging Changes Correlates With Reversal of Keratinocyte Fas Expression and Apoptosis
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J Gerontol A Biol Sci Med Sci 2004;59:B411-B415.
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An Immunoadhesin Incorporating the Molecule OX-2 Is a Potent Immunosuppressant That Prolongs Allo- and Xenograft Survival
Gorczynski et al.
J. Immunol. 1999;163:1654-1660.
ABSTRACT | FULL TEXT  





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