Essential Mixed CryoglobulinemiaA Comparative Study of Dermatologic Manifestations in Patients Infected or Noninfected With Hepatitis C Virus
Nicholas Dupin, MD;
Olivier Chosidow, MD;
François Lunel, MD;
Patrice Cacoub, MD;
Lucille Musset, PhD;
Pascale Cresta;
Lionel Frangeul;
Jean-Charles Piette, MD;
Pierre Godeau, MD;
Pierre Opolon, MD;
Camille Frances, MD
Arch Dermatol. 1995;131(10):1124-1127.
Abstract
Backgound and Design
An association between essential mixed cryoglobulinemia and hepatitis C virus (HCV) infection has been reported. Dermatologic manifestations are a classic presenting complaint in essential mixed cryoglobulinemia. The aim of this study was to compare the frequency and the nature of dermatologic manifestations in essential mixed cryoglobulinemia according to the presence of anti-HCV antibodies. Sixty-two consecutive patients with essential mixed cryoglobulinemia were tested for anti-HCV antibodies. Dermatologic manifestations were systematically assessed.
Results
Anti-HCV antibodies were detected in 35 patients. Palpable purpura corresponding histologically to leukocytoclastic vasculitis was the more frequently observed dermatologic manifestation and occurred mainly in HCV-antibody-positive patients. The patients with purpura had significantly higher serum cryoglobulin levels than patients without purpura.
Conclusions
The frequency of palpable purpura is higher in HCV-antibody-positive patients and is related to the serum cryoglobulin levels.
(Arch Dermatol. 1995;131:1124-1127)
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