This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Comparative Study of Dermatologic Manifestations in Patients Infected or Noninfected With Hepatitis C Virus

Nicholas Dupin, MD; Olivier Chosidow, MD; François Lunel, MD; Patrice Cacoub, MD; Lucille Musset, PhD; Pascale Cresta; Lionel Frangeul; Jean-Charles Piette, MD; Pierre Godeau, MD; Pierre Opolon, MD; Camille Frances, MD

Arch Dermatol. 1995;131(10):1124-1127.

Abstract
Backgound and Design
An association between essential mixed cryoglobulinemia and hepatitis C virus (HCV) infection has been reported. Dermatologic manifestations are a classic presenting complaint in essential mixed cryoglobulinemia. The aim of this study was to compare the frequency and the nature of dermatologic manifestations in essential mixed cryoglobulinemia according to the presence of anti-HCV antibodies. Sixty-two consecutive patients with essential mixed cryoglobulinemia were tested for anti-HCV antibodies. Dermatologic manifestations were systematically assessed.

Results
Anti-HCV antibodies were detected in 35 patients. Palpable purpura corresponding histologically to leukocytoclastic vasculitis was the more frequently observed dermatologic manifestation and occurred mainly in HCV-antibody-positive patients. The patients with purpura had significantly higher serum cryoglobulin levels than patients without purpura.

Conclusions
The frequency of palpable purpura is higher in HCV-antibody-positive patients and is related to the serum cryoglobulin levels.

(Arch Dermatol. 1995;131:1124-1127)

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Influence of inherited and acquired thrombophilic defects on the clinical manifestations of mixed cryoglobulinaemia
Casato et al.
Rheumatology (Oxford) 2008;47:1659-1663.
ABSTRACT | FULL TEXT  

Hepatitis C-associated mixed cryoglobulinaemia: a crossroad between autoimmunity and lymphoproliferation
Saadoun et al.
Rheumatology (Oxford) 2007;46:1234-1242.
ABSTRACT | FULL TEXT  

Hepatitis C Virus-Related Skin Diseases
Doutre
Arch Dermatol 1999;135:1401-1403.
FULL TEXT  

Detection of Antineutrophil Cytoplasmic Antibodies in Patients With Hepatitis C Virus-Induced Cutaneous Vasculitis With Mixed Cryoglobulinemia
Romani et al.
Arch Dermatol 1996;132:974-975.
ABSTRACT