Neutrophilic Dermatoses During Granulocytopenia
Sélim Aractingi, MD;
Valérie Mallet, MD;
Laure Pinquier, MD;
Olivier Chosidow, MD;
Marie-Dominique Vignon-Pennamen;
Laurent Degos, MD;
Louis Dubertret, MD;
Hervé Dombret, MD
Arch Dermatol. 1995;131(10):1141-1145.
Abstract
Background and Design
Noninfectious cutaneous neutrophilic lesions can occur during granulocytopenia, but their mechanism remains unknown. We undertook a retrospective study of the neutrophilic dermatoses that developed during granulocytopenia induced by chemotherapy for acute myelogenous leukemia.
Results
Seven men and one woman were included (2.6% of treated cases of acute myelogenous leukemia); half had acute myelogenous leukemia subtypes 4 and 5. The male-to-female ratio was 7:1. Neutrophilic eccrine hidradenitis was diagnosed in five cases, Sweet's syndrome in two cases, and difficult-to-classify neutrophilic dermatoses in one case. Cutaneous lesions appeared 12.5 days after the start of chemotherapy, and the mean leukocyte count was 0.426x 109/L. Three patients needed corticosteroids systemically.
Conclusion
Neutrophilic dermatoses during chemotherapy-induced granulocytopenia seem to occur more frequently in men with acute myelogenous leukemia subtypes 4 and 5.
(Arch Dermatol. 1995;131:1141-1145)
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