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A Review

Jean-Michel Pawlotsky, MD; Daniel Dhumeaux, MD; Martine Bagot, MD, PhD

Arch Dermatol. 1995;131(10):1185-1193.

Abstract
Background
Hepatitis C virus (HCV) is the main causative agent of parenterally transmitted non-A, non-B viral hepatitis. Infections with HCV may be associated with disorders of various organs other than the liver, essentially through immunologic mechanisms.

Objectives
To provide an update on HCV and to review and discuss dermatologic disorders directly or indirectly related to HCV-induced liver disease.

Observations
The main dermatologic disorders in HCV infection include (1) vasculitis (mainly cryoglobulinassociated vasculitis, the cause of which is HCV in most cases, and, possibly, some cases of polyarteritis nodosa); (2) sporadic porphyria cutanea tarda; (3) cutaneous and/or mucosal lichen planus; and (4) salivary gland lesions, characterized by lymphocytic capillaritis, sometimes associated with lymphocytic sialadenitis resembling that of Sjögren's syndrome.

Conclusions
Hepatitis C virus is the cause of, or is associated with, various dermatologic disorders. In patients with such disorders, HCV infection must be sought routinely because antiviral therapy may be beneficial in some of them.

(Arch Dermatol. 1995;131:1185-1193)

Author Affiliations
From the Departments of Bacteriology and Virology (Dr Pawlotsky), Hepatology and Gastroenterology (Dr Dhumeaux), and Dermatology (Dr Bagot), Hôpital Henri Mondor, Université Paris XII, Créteil, France.

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