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Sawomir Majewski, MD; Stefania Jaboska, MD

Arch Dermatol. 1995;131(11):1312-1318.

Abstract
Background
Epidermodysplasia verruciformis is a rare lifelong disease that has raised an enormous interest since it is a model of cutaneous genetic cancer induced by specific human papillomaviruses.

Observations
The interacting immunogenetic and environmental factors, especially UV irradiation, result in the inability of the patients' immune system to respond to epidermodysplasia verruciformis—specific human papillomaviruses. The local immunosuppression is an effect, at least in part, of the overproduction of tumor necrosis factor a and transforming growth factor β₁ and of the excessive formation of cis—urocanic acid.

Conclusions
Epidermodysplasia verruciformis is a model not only of cutaneous viral oncogenesis but also of local defense mechanisms in the progression of human papillomavirus—associated cancers.

(Arch Dermatol. 1995;131:1312-1318)

Author Affiliations
From the Department of Dermatology, Warsaw (Poland) School of Medicine.

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