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Mark D. Hoffman, MD; Matthew G. Fleming, MD; Roger W. Pearson, MD

Arch Dermatol. 1995;131(5):586-589.

Abstract
Background
We describe a new variant of inherited epidermolysis bullosa and elucidate the clinical, histologic, and ultrastructural features of this condition.

Observations
This form of epidermolysis bullosa displays an autosomal dominant inheritance pattern, is characterized by acral bullae, and histologically demonstrates suprabasal clefting with acantholysis. Ultrastructural findings are nonspecific but reminiscent of those observed in benign familial pemphigus.

Conclusion
Acantholytic epidermolysis bullosa is a rare but distinct clinicopathologic entity that warrants inclusion in the nosologic classification of epidermolysis bullosa.

(Arch Dermatol. 1995;131:586-589)

Author Affiliations
From the Department of Dermatology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill.

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